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Dtsch Med Wochenschr 2008; 133(45): 2345-2348
DOI: 10.1055/s-0028-1100926
DOI: 10.1055/s-0028-1100926
Arzneimittel und Pharmakotherapie | Review article
Pharmakologie, Onkologie
© Georg Thieme Verlag KG Stuttgart · New York
Posaconazol: Ein weiteres Triazol-Antimykotikum der neuen Generation?
Posaconazole: Another triazole antifungal of the new generation?Weitere Informationen
Publikationsverlauf
eingereicht: 18.4.2008
akzeptiert: 11.9.2008
Publikationsdatum:
28. Oktober 2008 (online)
Schlüsselwörter
Posaconazol - Triazolantimykotikum - Hämato-Onkologie - Lanosterol-14α-Demethylase - Cytochrom-P450-Enzyme - Pharmakokinetik - Arzneimittelinteraktionen
Keywords
Posaconazole - triazole antifungal drug - hemato-oncology - lanosterol-14α-demethylase - cytochrome-P450-enzyme - pharmacokinetics - drug-drug-interactions
Literatur
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- 3 Fachinformation zu Noxafil® SEB. 2007, Oktober
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- 8 Raad II. et al . Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections. Clin Infect Dis. 2006; 42 1726-1734
- 9 Raad II. et al . Novel antifungal agents as salvage therapy for invasive aspergillosis in patients with hematologic malignancies: posaconazole compared with high-dose lipid formulations of amphotericin B alone or in combination with caspofungin. Leukemia. 2008; 22 496-503
- 10 Smith J. et al . Therapeutic drug monitoring of antifungals: pharmacokinetic and pharmacodynamic considerations. Ther Drug Monit. 2008; 30 167-172
- 11 Ullmann A J. et al . Pharmacokinetics, safety, and efficacy of posaconazole in patients with persistent febrile neutropenia or refractory invasive fungal infection. Antimicrob Agents Chemother. 2006; 50 658-666
- 12 Ullmann A J. et al . Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease. N Engl J Med. 2007; 356 335-347
- 13 Walsh T J. et al . Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial. Clin Infect Dis. 2007; 44 2-12
- 14 Wexler D. et al . Effect of posaconazole on cytochrome P450 enzymes: a randomized, open-label, two-way crossover study. Eur J Pharm Sci. 2004; 21 645-653
Dr. med. Carsten Müller
Institut für Pharmakologie, Universität
zu Köln
Gleueler Str. 24
50931 Köln
Telefon: 0221/478-5066
Fax: 0221/478-7184
eMail: c.mueller@uni-koeln.de