Dtsch Med Wochenschr 2008; 133(45): 2332-2336
DOI: 10.1055/s-0028-1100924
Aktuelle Diagnostik & Therapie | Review article
Intensivmedizin
© Georg Thieme Verlag KG Stuttgart · New York

Immunmonitoring bei SIRS und Sepsis auf Grundlage des PIRO-Modells

Immune monitoring in SIRS and Sepsis based on the PIRO modelC. Meisel1 , C. Höflich1 , H.-D Volk1
  • 1Institut für Medizinische Immunologie, Charité Universitätsmedizin Berlin, Campus Mitte
Weitere Informationen

Publikationsverlauf

eingereicht: 2.6.2008

akzeptiert: 1.9.2008

Publikationsdatum:
28. Oktober 2008 (online)

Zusammenfassung

Sepsis stellt eine lebensbedrohliche Erkrankung dar, deren Pathogenese durch ein komplexes Zusammenwirken von Infektionserregern und Immunsystem charakterisiert ist. Das Monitoring immunologischer Parameter in Sepsispatienten und Patienten mit erhöhtem Sepsisrisiko kann helfen, prädisponierende Faktoren, den aktuellen Funktionszustand des Immunsystems sowie infektionsspezifische Reaktionsmuster zu erkennen und daraus personalisierte Therapiestrategien zu entwickeln. Ausgehend von dem PIRO-Modell als pathophysiologisch ausgerichtetem Konzept zur Entwicklung einer neuen Sepsis-Klassifikation fassen wir einige der aktuell angewandten bzw. diskutierten Parameter zum Immunmonitoring bei SIRS und Sepsis zusammen.

Summary

Sepsis is a life-threatening disease characterized by a complex interaction between pathogens and the immune system. The analysis of immune parameters in patients with sepsis or at risk for sepsis may help to identify predisposing factors and infection-specific reaction patterns, as well as to monitor the current functional state of the immune system. This may lead to personalized therapeutic strategies for improving outcome in sepsis. Based on the PIRO model (predisposition, insult, response, organ dysfunction), a pathophysiologically-oriented concept for the development of a new sepsis classification, this article reviews currently used and new parameters for immunmonitoring in SIRS (systemic inflammtory response syndrome) and sepsis.

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Dr. med. Christian Meisel

Institut für Medizinische Immunologie, Charité Campus Mitte

Charitéplatz 1

10117 Berlin

Telefon: 030/450524-062

Fax: 030/450524-932

eMail: chr.meisel@charite.de