Exp Clin Endocrinol Diabetes 2009; 117(7): 324-328
DOI: 10.1055/s-0028-1100424
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Echocardiographic Evaluation of Left and Right Ventricular Function in Subclinical Hypothyroidism

R. H. A. Fonseca 1 , P. F. S. Teixeira 2 , M. M. Ferreira 2 , M. M. T. Duarte 1 , V. S. Reuters 2 , C. P. Almeida 2 , M. Vaisman 2
  • 1Cardiology Service- Clementino Fraga Filho University Hospital
  • 2Federal University of Rio de Janeiro
Further Information

Publication History

received 04.05.2008 first decision 20.08.2008

accepted 21.10.2008

Publication Date:
26 February 2009 (online)

Abstract

Objective: The aim of the present study was to evaluate rest systolic and diastolic cardiac function by echocardiography in subclinical hypothyroidism (SH).

Methods: A cross sectional study was performed and the results obtained in the evaluation of two groups (SH and euthyroidism) were compared. Subjects with systemic arterial hypertension, diabetes or cardiovascular diseases, or that in use of drugs that influence thyroid function were excluded.

Results: The two groups (SH=37; euthyroidism=35) had similar demographic characteristics as age, Blood Pressure, Body Mass Index and frequencies of sedentarism, tabagism, menopause. There was a tendency to diastolic dysfunction, with higher median values of Deceleration Time of mitral E wave in the SH group (230 vs. 216 ms; p=0.053), which was also slightly positively associated with serum TSH levels (rs=0.154; p=0.095). As expected, Deceleration Time was negatively correlated with E wave velocity (rs=−0.353; p=0.001) and E/A index (rs=−0.238; p=0.022) and was powerless positively associated with Isovolumic Relaxation Time (rs=0.178; p=0.067) and A wave velocity (rs=0.177; p=0.069). It was not detected left systolic dysfunction, since there were not differences in the means of cardiac output, ejection fraction, ejection time, fractional shortening, isovolumic contraction time and Myocardium performance index of LV.

Conclusion: We did not detect left systolic dysfunction at rest in SH but the findings corroborate with the possibility of diastolic dysfunction in SH group.

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Correspondence

Dr. P. F. S. Teixeira

UFRJ

Prof Rodolpho Paulo Rocco

255 Rio de Janeiro

21941-913 Brazil

Phone: +55/23/250 27 48

Fax: +55/23/2562 27 48

Email: pfatima@hucff.ufrj.br