EXPERIMENTAL STUDIES ON THE EFFECT OF GLYCYRRHIZA GLABRA

Summary

The results of these experiments done on dogs to investigate the effects of Glycyrrhiza extract can be summarized as follows:

1. The extract produced inhibition of the intestinal movements. It was shown that this action was anti–cholinergic as it blocked the stimulatory effect of acetylcholine.

2. It had an anthelmintic influence upon taenia worms, while ascaris did not respond to the extract.

3. It caused relaxation of the uterine musculature of both pregnant and non–pregnant bitches.

4. The frequency of respiration remained unaffected up to 800 mg./kg. body weight.

5. The extract of the plant had a slight hypotensive effect which was temporary.

Zusammenfassung

Die Untersuchungen der Wirkung des Extraktes von Glycyrrhiza am Hund zeitigten folgende Ergebnisse:

1. Hemmung der Darmbewegung.

2. Anthelmintischer Einfluß auf Taenia, wogegen Ascaris nicht reagierte.

3. Entspannung der Uterus–Muskulatur bei tragenden und nicht tragenden Hündinnen.

4. Die Atmungsfrequenz blieb bis zu 800 mg/kg Tier unbeeinflußt.

5. Eine leichte, nur zeitweilige, hypotensive Wirkung.