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Planta Med 1977; 31(1): 51-56
DOI: 10.1055/s-0028-1097489
© Georg Thieme Verlag Stuttgart · New York

THE STRUCTURE AND BIOLOGICAL EFFECT OF LEONURINE

A Uterotonic Principle from the Chinese Drug, I–mu Ts'aoH. W. Yeung1 , Y. C. Kong1 , W. P. Lay2 , K. F. Cheng3
  • 1Department of Biochemistry, Chinese University of Hong Kong, Shatin, N.T., Hong Kong
  • 2Department of Chemistry, Chinese University of Hong Kong
  • 3Department of Chemistry, University of Hong Kong
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Publication Date:
13 January 2009 (online)

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Abstract

A uterotonic principle of the Chinese drug I–mu Ts'ao, Leonurus artemisia, was obtained by fractionating the crude acidic methanol extract of the plant on aluminium oxide and Sephadex G–25 columns successively. The structure of this uterotonic compound was determined by ir, NMR and ms to be leonurine and confirmed by comparison to a synthetic product. The uterotonic properties of leonurine were examined on isolated rat uterus.