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Planta Med 1979; 36(6): 156-163
DOI: 10.1055/s-0028-1097256
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Liver–protective Principle of Thujopsis dolabrata Leaves1

Hiroshi Hikino1 , Toshizi Sugai1 , Chohachi Konno1 , Ichio Hashimoto2 , Shigeru Tërasaki3 , Iwao Hirono4
  • 1Pharmaceutical Institute, Tohoku University, Sendai.
  • 2College of Medical Sciences, Tohoku University, Sendai.
  • 3Central Clinical Laboratories, Tohoku University School of Medicine, Sendai.
  • 4Institute of Medical Science, University of Tokyo, Tokyo, Japan.
1 Liver–protective drugs, Part 1. Also Part 6 in the series on the validity of the Oriental medicines. [Part 5: Planta Medica 34, 150 (1979).]
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Publikationsdatum:
13. Januar 2009 (online)

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Siehe auch:

Cardioactive Principle of Aconitum carmichaeli Roots1Planta Med 1979; 35(02): 150-155
DOI: 10.1055/s-0028-1097196

Abstract

The protective action of methanol extract of a Japanese folklore medicine „asunaro–yo”, Thujopsis dolabrata leaves, on CCl4–induced liver damage in mice has been assessed with a liver function test to reveal that some extracts are effective for protection of the experimental liver lesion. One of the extracts has been fractionated, monitored by the serum enzyme assay, furnishing a lignan, desoxypodophyllotoxin, as the active principle. The protective effect of desoxypodophyllotoxin against CCl4 hepatotoxicity has been shown by liver function tests as well as by pathological examinations. Desoxypodophyllotoxin had no appreciable effect on the serum enzyme activity of normal mice. Remarkable variation has been found in the content of the active principle desoxypodophyllotoxin and consequently the protective activity of the leaves.

Key Word Index

Thujopsis dolabrata - Cupressaceae - Lignan - Desoxypodophyllotoxin - Carbon Tetrachloride Hepatotoxicity - Liver–protective Effect