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DOI: 10.1055/s-0028-1097207
© Georg Thieme Verlag Stuttgart · New York
Neue Enzyminhibitoren aus Mikroorganismen
New Enzyme Inhibitors from MicroorganismsPublication History
Publication Date:
13 January 2009 (online)
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Abstract
A literature survey on the structures and specificities of enzyme inhibitors isolated from microorganisms is presented, with special emphasis on protease inhibitors and inhibitors of adrenaline metabolism.
In addition a new group of glycoside hydrolase inhibitors isolated from actinomycetes is discussed in detail, with special reference to detection, production, pharmacological effects and structure of the inhibitors. An integral part in the chain of α–1,4–linked D–glucopyranose units is a core structure consisting of an unsaturated cyclitol unit bound to 4,6–dideoxy–4–amino–D–glucopyranose.
The low molecular weight homologues are potent sucrase inhibitors whereas the inhibitors of higher molecular weight are specific for α–amylase.
Key Word Index
Enzyme Inhibitors - Protease Inhibitors - Amylase Inhibitors - Sucrase Inhibitors - Microorganisms - Actinomycetes