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Horm Metab Res 1970; 2(2): 68-71
DOI: 10.1055/s-0028-1095110
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© Georg Thieme Verlag KG Stuttgart · New York

Response of Serum Insulin Concentration to Tumor Growth in Different Genetic Systems[*]

G. L. Wolff , G. A. Reichard Jr.
  • The Institute for Cancer Research and Smith, Kline & French Laboratories, Philadelphia, Pa., USA
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

Genetic and hormonal factors and their interaction in the regulation of serum insulin level in mice have been examined. The inbred YS/ChWf and VY/Wf strains each segregate into two genotypes which differ in their mean serum insulin level. YS/ChWf produces yellow Ay/a and non-yellow a/a offspring; VY/Wf produces yellow Avy/a and non-yellow a/a young.

Serum insulin levels in yellow YS males are lower than in their a/a brothers. However, in yellow VY males, these levels are higher than in a/a VY males. Response of serum insulin concentration to growth of an allogeneic tumor also differs between the two strains. Levels are increased in both VY genotypes while there is no change in the yellow YS mice and a decrease in the non-yellow YS mice. Castration had no effect on the serum insulin concentration in yellow YS males but reduced it to an extremely low value in the non-yellow YS males.

Serum insulin levels and their response to growth of allogeneic tumor were also studied in several F1 hybrids between these strains. The data indicate that the YS genome exerts a depressing effect on serum insulin concentration and that this effect is decreased when combined with the VY genome.

The Avy/a genotype seems to induce a higher serum insulin concentration and greater response to tumor growth than the Ay/a genotype.

Key words

Serum Insulin - Tumor Growth - Castration - Mouse Genotypes

1 The portion of the work performed by G. L. Wolff was supported by U.S.P.H.S. grants CA-06927 and FR-05539 and by an appropriation from the Commonwealth of Pennsylvania.

1 The portion of the work performed by G. L. Wolff was supported by U.S.P.H.S. grants CA-06927 and FR-05539 and by an appropriation from the Commonwealth of Pennsylvania.