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Horm Metab Res 1970; 2(3): 147-152
DOI: 10.1055/s-0028-1095104
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© Georg Thieme Verlag KG Stuttgart · New York

Effect of Nicotinamide on the Regulation of Carbohydrate Metabolism in Rat Liver[* ]

H.  Talke , J.  Keller [**] , F. W. Schmahl [***]
  • Medizinische Universitätsklinik, Freiburg, Germany
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

Male Sprague-Dawley rats received an intraperitoneal injection of 500 mg nicotinamide/kg body weight. One, two, five and eight hours later, the livers were frozen rapidly in liquid N2. The following metabolites were analyzed: lactate, pyruvate, glycerol-I-phosphate, dihydroxyacetone-phosphate, malate, oxaloacetate, adenine nucleotides, glucose, glucose-6-phosphate, fructose-1,6-diphosphate, phospho-enolpyruvate, acetyl-Coenzyme A, nicotinamide-adenine dinucleotide, nicotinamide-adenine dinucleotide phosphate. In addition, the levels of glycogen and triglycerides were determined.

Key words

Nicotinamide - Inhibition of Lipolysis - Redoxstate of the Cytosolic NAD-System - Gluconeogenesis

1 Parts of this report were first presented at Verhandl. Dt. Ges. inn. Med., Wiesbaden (22-25 April 1968).

1 Parts of this report were first presented at Verhandl. Dt. Ges. inn. Med., Wiesbaden (22-25 April 1968).

2 Present address: Biochem. Institut der Univ. Freiburg, FRG.

3 Present address: Med. Kliniken und Polikliniken der Univ. Gießen, FRG.