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DOI: 10.1055/s-0028-1095052
© Georg Thieme Verlag KG Stuttgart · New York
Inhibition of Glyceraldehyde-3-Phosphate Dehydrogenase by Follicle-Stimulating Hormone Preparations In Vitro
Publikationsverlauf
Publikationsdatum:
08. Januar 2009 (online)
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Abstract
Rabbit muscle GAPDH (E.C.1.2.1.12) was inhibited by two preparations of FSH, one ovine and the other porcine. A third preparation, also of ovine origin, did not inhibit this enzyme. This suggested that the inhibition was not due to FSH but a contaminant. This inhibition of glyceraldehyde-3-phosphate dehydrogenase was specific. None of the other pituitary hormones had any effect on this enzyme and other NAD-linked and NADP-linked dehydrogenases were not inhibited by these FSH preparations.
Abbreviations used
ADH = alcohol dehydrogenase
EDTA= disodium ethylenedinitrilotetracetate
FSH = follicle-stimulating hormone
GDH = L-glutamic dehydrogenase
G6PDH = glucose-6-phosphate dehydrogenase
GAPDH = glyceraldehyde-3-phosphate dehydrogenase
LH = luteinizing hormone
α-MSH = α-melanocyte-stimulating hormone
6PGDH = 6-phosphogluconate dehydrogenase
STH = growth hormone
TSH = thyroid-stimulating hormone
Key words
Follicle-Stimulating Hormone - Glyceraldehyde 3-Phosphate Dehydrogenase - Growth Hormone - Pituitary Hormone
1 Present address: Department of Biological Chemistry, Harvard University Medical School, Boston, Massachusetts 0215