Augmentation by Dihydroergotamine of Lipolysis Stimulated by Whole and Pepsin-Digested Human Growth Hormone

A. Kowadlo-Silbergeld; I. Klipper; S. Assa; Z. Laron

doi:10.1055/s-0028-1094046

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Horm Metab Res 1972; 4(3): 187-190
DOI: 10.1055/s-0028-1094046

Originals

Augmentation by Dihydroergotamine of Lipolysis Stimulated by Whole and Pepsin-Digested Human Growth Hormone[*]

A. Kowadlo-Silbergeld , I. Klipper , S. Assa , Z. Laron

Pediatric Metabolic and Endocrine Service and Rogoff-Wellcome Medical Research Institute, Beilinson Hospital, Department of Physiology, Tel Aviv University Medical School, Israel

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Publikationsverlauf

Publikationsdatum:
07. Januar 2009 (online)

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Abstract

Dihydroergotamine was found to significantly enhance the lipolytic response of rat adipocytes and tissue sements to human growth hormone, whether whole or pepsin-digested. The effect was dexamethasone dependent, and was inhibited by cycloheximide.

Key words

Lipolysis - Isolated Fat Cells - Dihydroergotamine - Human Growth Hormone - Peptic Digestion - Cycloheximide

1 Presented in part at the 2nd International Symposium on Growth Hormone, Milan, May 5-7,1971.