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Horm Metab Res 1972; 4(5): 325-327
DOI: 10.1055/s-0028-1094025
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© Georg Thieme Verlag KG Stuttgart · New York

Glycolytic Intermediates in Human Adipose Tissue of Diabetic and Obese Patients During Glucose Tolerance Tests

R.  Guttman , D. J. Galton [*]
  • Endocrine Unit, Department of Medicine, Royal Postgraduate Medical School, London, England
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

The levels of glucose-6-phosphate and L-glycerol 3-phosphate have been measured in adipose tissue of adult diabetics and non-diabetic obese patients. Despite greatly different blood glucose concentrations, the intermediates were maintained at similar levels in adipose tissue of both groups of patients. The levels of both intermediates fluctuated during a glucose tolerance test. This was most marked with glucose-6-phosphate which in diabetics failed to return to initial values after two hours (p < 0.01).

Key words

Human Adipose Tissue - Glucose-6-Phosphate - Glycerol-Phosphate - Diabetes - Obesity

1 Present address: Department of Medicine, St. Bartholomew's Hospital, London, E.C.I (England)