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Horm Metab Res 1973; 5(4): 283-285
DOI: 10.1055/s-0028-1093948
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Time and Level of Increased Plasma Corticosterone Necessary for Induction of Liver Tyrosine Aminotransferase in Rats Subjected to Trauma

Š.  Németh , M.  Vigaš , A.  Straková
  • Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Czechoslovakia
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Publication Date:
07 January 2009 (online)

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Abstract

In male, adult rats, adrenalectomized immediately or 15 minutes after a dose of 6 minutes and 40 seconds (= 400 revolutions) in the Noble-Collip drum, a decrease with a half time of approximately 15 minutes for plasma corticosterone was found. However, a posttraumatic increase of liver tyrosine aminotransferase activity could be observed only in the animals, adrenalectomized 15 minutes after injury, whereas in rats, adrenalectomized immediately after it, this response was completely absent. From our results, a plasma corticosterone level of about 50-60 µgm/100 ml, lasting for at least 15 minutes seems to be necessary for enzyme activation.

Key words

Liver Tyrosine Aminotransferase - Liver Glycogen - Plasma Corticosterone - Half Time of Plasma Corticosterone - Trauma - Enzyme Protein Synthesis - Adrenalectomy - Rat