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Horm Metab Res 1974; 6(1): 36-40
DOI: 10.1055/s-0028-1093900
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© Georg Thieme Verlag KG Stuttgart · New York

Studies on the Pituitary "Fettstoffwechselhormon" - V. The Further Purification of Lipolytic Active Peptides from Hog Pituitary Glands[*]

M.  Schleyer , H. L. Fehm , K. H. Voigt , J. D. Faulhaber , E. F. Pfeiffer
  • Department of Endocrinology and Metabolism, Department of Metabolism and Nutrition, Center of Internal Medicine and Pediatrics, University of Ulm, Germany
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

As recently reported we isolated from a lipolytically active pituitary crude fraction P IV three other peptides which showed lipolytic activity but also some corticotropic activity. From these three fractions we obtained twelve other subfractions by ion exchange chromatography. Three of these fractions showed high lipid mobilizing effects. For two of these lipolytic fractions no corticotropic activity was demonstrable by the radioimmunological assay; in vitro these two fractions did not stimulate the corticosterone secretion. Herewith, it was for the first time possible to isolate peptides from hog pituitaries which showed high lipolytic activity but no corticotropic activity.

Key words

Lipolytic Hormone - Adrenocorticotropic Hormone

1 Supported by Deutsche Forschungsgemeinschaft, SFB 87. Parts of these studies were presented on the 19. Symposium of the Deutsche Gesellschaft für Endokrinologie, Berlin 1973 {Schleyer, Voigt, Faulhaber, Fehm and Pfeiffer 1973).

1 Supported by Deutsche Forschungsgemeinschaft, SFB 87. Parts of these studies were presented on the 19. Symposium of the Deutsche Gesellschaft für Endokrinologie, Berlin 1973 {Schleyer, Voigt, Faulhaber, Fehm and Pfeiffer 1973).