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Horm Metab Res 1974; 6(1): 74-78
DOI: 10.1055/s-0028-1093888
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© Georg Thieme Verlag KG Stuttgart · New York

Renal Handling of Cortisol in Dogs - I. Free Flow Studies[*]

U.  Boonayathap [**] , S. F. Marotta
  • Department of Physiology, University of Illinois, School of Basic Medical Sciences, Chicago, Illinois, U.S.A.
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Publikationsdatum:
07. Januar 2009 (online)

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Abstract

The renal excretion of free and glucuronide conjugated Cortisol over a wide range of plasma Cortisol concentrations was studied in anesthetized dogs. The results indicate that the tubular reabsorption of free Cortisol reached a maximum when the filtered load was approximately 14 µg/min. The tubular maximum of free Cortisol was below 9 µg/min and the plasma threshold was about 10 µg/100 ml plasma. Cortisol glucuronide, which did not exhibit a tubular maximum or a plasma threshold, was handled by the canine kidney both by secretion and reabsorption.

Key words

Renal Cortisol Reabsorption - Threshold - Tubular Maximum

1 These studies were supported in part by internal grants of the University of Illinois and the Office of Naval Research Contract NR 101-580.

1 These studies were supported in part by internal grants of the University of Illinois and the Office of Naval Research Contract NR 101-580.

2 Present address: Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.