Download PDF
Horm Metab Res 1974; 6(5): 392-396
DOI: 10.1055/s-0028-1093831
Originals

© Georg Thieme Verlag KG Stuttgart · New York

Inhibition of Glucagon Secretion in the Human Newborn by Simultaneous Administration of Glucose and Insulin

F.  Massi-Benedetti , A.  Falorni , A.  Luyckx [*] , P.  Lefebvre
  • Department of Pediatrics, University of Perugia, Italy, and
    Division of Diabetes, Institute of Medicine, University of Liège, Belgium
Further Information

Publication History

Publication Date:
07 January 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

Glucose (1 gm/kg body weight) was administered intraportally to newborn infants, either alone or with intraportal insulin (0.1 or 0.3 U/kg body weight). As shown earlier, glucose alone did not suppress portal plasma glucagon; in contrast glucose plus insulin (at both doses used) resulted in a significant decrease in portal plasma glucagon. These data support the concept that insulin plays an important role in the physiologic sensitiveness of the alpha cell to glucose.

Key words

Insulin - Glucagon - Glucose - Human Newborn - Alpha Cell - Beta Cell - Glucose Homeostasis

1 Chargé de Recherches du Fonds National de la Recherche Scientifique (Belgium)