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Horm Metab Res 1975; 7(6): 499-501
DOI: 10.1055/s-0028-1093712
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© Georg Thieme Verlag KG Stuttgart · New York

The Plasmatic 11-Hydroxy-Corticosteroid Response in the Human to a Synthetic Octadecapeptide Corticotropin (C-41795-Ba)[*]

F.  Duran , J.  Torres , A.  Charro1 , A. Oriol Bosch
  • Department for Experimental Endocrinology, University Complutensis Medical School, Madrid, Spain
  • 1Department for General Pathology, University Complutensis Medical School, Madrid, Spain
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Publikationsdatum:
23. Dezember 2008 (online)

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Abstract

The adrenal response as measured by the plasmatic changes in 11-hydroxy-corticosteroid (11-OHCS) concentration following the administration of a synthetic octadecapeptide (C-41795-Ba) was compared in 17 normal young males with that obtained with the commercially available tetracosactrin. C-41795-Ba polypeptide shows a higher potency than tetracosactrin. Its effects are longer lasting when administered intravenously which indicates a significant local inactivation of the polypeptide.

Key words

ACTH - Adrenal Gland - 11-OHCS

1 Part of the results were presented at the 14 Meeting of the Spanish Society for Physiological Sciences, 1973.

1 Part of the results were presented at the 14 Meeting of the Spanish Society for Physiological Sciences, 1973.