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Horm Metab Res 1975; 7(6): 471-475
DOI: 10.1055/s-0028-1093706
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© Georg Thieme Verlag KG Stuttgart · New York

Effect of Fat Cell Size, Restrictive Diet and Diabetes on Lipoprotein Lipase Release by Human Adipose Tissue[*]

B.  Guy-Grand , B.  Bigorie
  • Clinique Médicale de l'Hôtel-Dieu, U.E.R. Broussais University Paris VI , Paris, France
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Publication Date:
23 December 2008 (online)

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Abstract

The lipoprotein lipase activity (LPLA) eluted from human adipose tissue was measured after percutaneous biopsy in the fasting state.

A positive and significant correlation was found between LPLA per 106 cells or per cell surface unit and cell volume in 27 normal and obese subjects in weight balance and on maintenance diet. Such a correlation was also found in 13 diabetic subjects before treatment.

In 11 obese subjects subjected to a restricted diet, LPLA dropped dramatically without a significant change in cell size, blunting the cell size effect.

In diabetic subjects the LPLA per cell was significantly lower than in nondiabetic people with similar adipose cell volume.

Key words

Lipoprotein Lipase - Adipose Tissue - Fat Cells - Human - Obesity - Diabetes - Restrictive Diet

1 Supported by Credits de recherche Université Paris IV and CNAMTS grant.

1 Supported by Credits de recherche Université Paris IV and CNAMTS grant.