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Horm Metab Res 1976; 8(3): 206-211
DOI: 10.1055/s-0028-1093661
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© Georg Thieme Verlag KG Stuttgart · New York

The Different Modes of Action of Thyrotropin and Prostaglandin E1 on Cyclic Adenosine 3',5'-Monophosphate Synthesis in Human Thyroid, as Studied by Sequential Stimulations[*]

N.  Takasu , S.  Sato , T.  Yamada , M.  Makiuchi , R.  Furihata , M.  Miyakawa
  • Department of Medicine, Institute of Adaptation Medicine, and Second Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Japan
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

PGE1 was equally effective in increasing 3H-cyclic AMP in normal and in toxic thyroids, whereas TSH was less effective but over a longer time in the toxic thyroids. Stimulation by a large second dose of TSH could not be elicited after prior stimulation by large doses of TSH. Similar results were obtained with regard to the effect of PGE1. However, stimulation by a large dose of PGE1 was still effective after the slices became refractory to TSH. Similarly, stimulation by a large dose of TSH was still effective after the slices became refractory to PGE1. It is suggested that the site and/or mode of action of TSH is quite different from that of PGE1.

Key words

Thyrotropin - Prostaglandin E1 - Cyclic AMP - Human Thyroid

1 Supported by a Grant from the Ministry of Education of Japan

1 Supported by a Grant from the Ministry of Education of Japan