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Horm Metab Res 1978; 10(2): 161-167
DOI: 10.1055/s-0028-1093467
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© Georg Thieme Verlag KG Stuttgart · New York

An Estimation of the Parathyroid Hormone Secretion Rate in Vitamin D Deficient Rats

H.  Takahashi , E.  Shimazawa , N.  Horiuchi , T.  Suda , K.  Yamashita , E.  Ogata
  • Department of Pharmacology, Teikoku Hormone Mfg. & Co., Kawasaki, Kanagawa
    The Department of Biochemistry, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo
    Department of Medicine, University of Tsukuba, Niihari, Ibaraki, Japan
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Publication Date:
23 December 2008 (online)

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Abstract

In an attempt to define the rate of endogenous secretion of parathyroid hormone in vitamin D deficiency, graded amounts of hormone were infused constantly into vitamin D deficient and vitamin D fed acutely thyroparathyroidectomized rats in a perfusion balance study. The dose of hormone needed to compensate for acute thyroparathyroidectomy was estimated. Serum levels of calcium and phosphorus, renal clearances of phosphorus and urinary excretion of cyclic AMP, each determined 16 hr after the surgery, were employed as parameters of the hormone effect. It was concluded that, in the condition of the perfusion balance study, the secretion rate of parathyroid hormone was 5.1-8.6 USP u/hr in the vitamin D deficient animals compared with 0.81-0.84 USP u/hr in the control.

Key words

Vitamin D Deficiency - Parathyroid Hormone - Renal Clearances - Calcium - Phosphorus - Cyclic AMP