Dtsch Med Wochenschr 2008; 133(42): 2168-2172
DOI: 10.1055/s-0028-1091258
Prinzip & Perpektive | Review article
Viszeral- und Transplantationschirurgie
© Georg Thieme Verlag KG Stuttgart · New York

Akuter Sauerstoffmangel und Hypoxietoleranz

Oxygen deprivation and hypoxia toleranceM. Schneider1 , J. Weitz1
  • 1Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Heidelberg
Further Information

Publication History

eingereicht: 15.4.2008

akzeptiert: 23.7.2008

Publication Date:
07 October 2008 (online)

Literatur

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  • 2 Aragones J, Schneider M, Van Geyte K. et al . Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.  Nature genetics. 2008;  40 170-180
  • 3 Beall C M. High-altitude adaptations.  Lancet. 2003;  362 Suppl s14-15
  • 4 Bernhardt W M, Warnecke C, Willam C. et al . Organ protection by hypoxia and hypoxia-inducible factors.  Methods in enzymology. 2007;  435 221-245
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  • 7 Epstein A C, Gleadle J M, McNeill L A. et al . C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.  Cell. 2001;  107 43-54
  • 8 Fandrey J, Gorr T A, Gassmann M. Regulating cellular oxygen sensing by hydroxylation.  Cardiovasc Res. 2006;  71 642-651
  • 9 Kim J W, Tchernyshyov I, Semenza G L, Dang C V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.  Cell Metab. 2006;  3 177-185
  • 10 Majno G, Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death.  The American journal of pathology. 1995;  146 3-15
  • 11 Nangaku M, Eckardt K U. Hypoxia and the HIF system in kidney disease.  Journal of molecular medicine (Berlin, Germany). 2007;  85 1325-1330
  • 12 Schlaifer J D, Kerensky R A. Ischemic preconditioning: clinical relevance and investigative studies.  Clinical cardiology. 1997;  20 602-606
  • 13 Schmidt J, Muller S A, Mehrabi A, Schemmer P, Buchler M W. [Orthotopic liver transplantation: Techniques and results.].  Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen. 2008;  79 112-120
  • 14 Ramirez J M, Folkow L P, Blix A S. Hypoxia tolerance in mammals and birds: from the wilderness to the clinic.  Annual review of physiology. 2007;  69 113-143

Dr. med. Martin Schneider

Emmy Noether-Gruppenleiter, Universitätsklinikum Heidelberg, Abteilung für Allgemein-, Viszeral- und Transplantationschirurgie

Im Neuenheimer Feld 110

69120 Heidelberg

Phone: 06221/56-37876

Fax: 06221/56-5506

Email: martin.schneider@med.uni-heidelberg.de

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