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DOI: 10.1055/s-0028-1090226
© Georg Thieme Verlag KG Stuttgart · New York
Ernährung zur Beeinflussung des Stoffwechsels – oder umgekehrt?
Georg-Klemperer-Vorlesung 2009Influencing Metabolism Through Nutrition – or Vice Versa?Georg Klemperer Memorial Lecture 2009Publication History
Publication Date:
02 April 2009 (online)
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Vorwort des Verlags
Im Rahmen des edi-Kongress (ernährung – diätetik – infusionstherapie) in Berlin wurde am 28.2.2009 zum 2. Mal die Georg-Klemperer-Vorlesung gehalten. Diese bedeutende Auszeichnung der deutschen Ernährungsmedizin ging dieses Jahr an Herrn Professor Dr. med. Manfred J. Müller, Direktor des Instituts für Humanernährung und Lebensmittelkunde der Christian-Albrechts-Universität in Kiel. Der Namensgeber des Preises, Georg Klemperer (1865–1946), langjähriger Direktor des Krankenhauses Moabit, gilt als ein wichtiger Vorreiter der Ernährungsmedizin in Deutschland. In seiner Vorlesung schlägt Prof. M. J. Müller einen Bogen von Klemperers Beschäftigung mit dem Stoffwechsel, dessen Erforschung „in Krankheiten und verschiedenen Ernährungszuständen” Klemperer für unabdingbar hielt, zu den modernen Erkenntnissen über die Veränderungen des Stoffwechsels bei Krankheiten. Klemperer war noch überzeugt, angesichts der raschen „Konsumption” bei manchen Krankheiten, den Stoffwechsel des Kranken durch Ernährung beeinflussen zu können. Die heutige Auffassung zum Hypermetabolismus und „hypercatabolic cachexia” legt umgekehrt nahe, statt „Ernährung zur Beeinflussung des Stoffwechsels” die „Beeinflussung des Stoffwechsels zur Ernährung” als angemessene Option anzusehen.
Preface by the Publisher
Initiated in 2007, the biennial Georg Klemperer Memorial Lecture was held on February 28th, 2009, during the edi congress in Berlin (the national congress on nutrition, dietetics and infusion therapy in Germany). This year, Professor Manfred J. Müller, M.D., Director of the Institute of Human Nutrition and Food Science at the Christian Albrechts University, Kiel was awarded this prestigious prize in the field of nutritional medicine. The lecture is held in honour of Georg Klemperer (1865–1946), for many years director of the Moabit hospital in Berlin and a pioneer in the field of nutritional medicine in Germany. In his lecture, Professor Müller took a close look at Klemperer's favourite theory on human metabolism (Klemperer was certain that „understanding the human metabolism in sickness and in different nutritional statuses” was key to curing diseases) and compared Klemperer's ideas with today's insights into metabolic changes during different illnesses. Klemperer was convinced that, given the rapid „consumption” observable in certain conditions, it must be possible to influence a patient's metabolism through his diet; yet contemporary findings on hypermetabolism and hypercatabolic cachexia suggest the opposite. Instead of „influencing metabolism through nutrition” it is far more appropriate to think of „influencing the metabolism to ensure proper patient nutrition” as a possible – and plausible – therapeutic approach.
Literatur
- 1 Forßmann W. Selbstversuch. Erinnerungen eines Chirurgen. Düsseldorf; Droste Verlag 1972
- 2 Wolf U. Leben und Wirken des Berliner Internisten Georg Klemperer (1865–1946). Aachen; Shaker Verlag 2003
- 3 Klemperer G. Untersuchungen über Stoffwechsel und Ernährung in Krankheiten. Zeitschrift für Klinische Medicin. 1891; Band XVI 118-173
- 4 van der Leyden E, Klemperer G. Handbuch der Ernährungsmedizin und Diätetik, Band 1 und 2. Leipzig; Georg Thieme Verlag 1903
- 5 Müller M J, Bosy-Westphal A, Later W. et al . Functional body composition – insights into regulation of energy metabolism and some clinical applications. Eur J Clin Nutrition. 2009, im Druck;
- 6 Müller M J, Bosy-Westphal A, Klaus S. et al . World Health Organization equations have shortcomings for predicting resting energy expenditure in persons from a modern, affluent population: generation of a new reference standard from a retrospective analysis of a German database of resting energy expenditure. Am J Clinical Nutrition. 2004; 80 1379-1390
-
7 Müller M J, Bosy-Westphal A, Geisler C. et al .
Physiological vs pathological changes of nutritional status over life time. In: Lochs H, Thomas DR, eds Home care enteral feeding. Nestle Nutrition Workshop Series Clinical & Performance Program Vol. 10). Basel; Karger AG 2005: pp 31-43 - 8 Keys A. The Biology of Human starvation. Minneapolis MN; University of Minnesota 1950
- 9 Hall K D. Computational model of in vivo human energy metabolism during semistarvation and refeeding. Am J Physiol Endocrinol Metabol. 2006; 291 E23-E37
- 10 Weyer C, Pratley R E, Salbe A D. et al . Energy expenditure, fat oxidation, and body weight regulation: A study of metabolic adaptation to long-term weight change. J Clin Endocrinol Metabol.. 2000; 85 1087-1094
- 11 Weyer C, Vozarova B, Ravussin E. et al . Changes in energy metabolism in response to 48 h of overfeeding and fasting in Caucasians and Pima Indians. Intern J Obes. 2001; 25 593-600
- 12 Müller M J, Bosy-Westphal A, Kutzner D. et al . Metabolically active components of fat free mass and resting energy expenditure in humans: recent lessons from imaging technologies. Obes Rev. 2002; 3 113-122
- 13 Bursztein S, Elwyn D H, Askanazi J A. et al .Energy metabolism, indirect calorimetry, and nutrition. Baltimore; Williams & Wilkins 1989
- 14 Müller M J, Böttcher J, Selberg O. et al . Hypermetabolism in clinically stable patients with liver cirrhosis. Am J Clin Nutr. 1999; 69 1194-1201
- 15 Peng S, Plank L D, McCall J L. et al . Body composition, muscle function, and energy expenditure in patients with liver cirrhosis: a comprehensive study. Am J Clin Nutr. 2007; 85 1257-1266
- 16 Haas V, Onur S, Paul Th. et al . Leptin and body weight regulation in patients with anorexia nervosa before and during weight recovery. Am J Clin Nutr. 2005; 81 889-896
- 17 Müller M J. Malnutrition and hypermetabolism in patients with liver cirrhosis. Am J Clin Nutr. 2007; 85 1167-1168
- 18 Müller M J, Lautz H U, Plogmann B. et al . Energy expenditure and substrate oxidation in patients with cirrhosis: The impact of cause, clinical staging and nutritional state. Hepatology. 1992; 15 782-794
- 19 Selberg O. Radoch E, Walter GF et al. Skeletal muscle glycogen content in patients with cirrhosis. Hepatology. 1994; 20 135-141
- 20 Müller M J, Böker K HW, Selberg O. Metabolism of energy yielding substrates in patients with liver cirrhosis. Clin Investig. 1994; 72 568-579
- 21 Kelley D E. Skeletal muscle fat oxidation: Timing and flexibility are everything. J Clin Invest. 2005; 115 1699-1702
- 22 Selberg O, Böttcher J, Tusch G. et al . Identification of high- and low-risk patients before liver transplantation: a prospective cohort study of nutritional and metabolic parameters in 150 patients. Hepatology. 1997; 25 652-657
- 23 Hall K D, Baracos V. Computational modeling of cancer cachexia. Curr Opinion Clin Nutr Metab Care. 2008; 11 214-221
- 24 Herndon D N, Hart D W, Wolf S E. et al . Reversal of catabolism by beta-blockade after severe burns. N Engl J Med. 2001; 345 1223-1229
Prof. Dr. Manfred J. Müller
Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-Universität zu Kiel
Düsternbrooker Weg 17–19
24105 Kiel
Email: mmueller@nutrfoodsc.uni-kiel.de