Planta Med 2009; 75(2): 174-177
DOI: 10.1055/s-0028-1088345
Natural Products Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Alkaloids from Roots of Stemona sessilifolia and Their Antitussive Activities

Xin-Zhou Yang1 , Jian-Yu Zhu2 , Chun-Ping Tang1 , Chang-Qiang Ke1 , Ge Lin3 , Tin-Yan Cheng3 , John A. Rudd3 , Yang Ye1
  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. China
  • 2Shanghai Institute of Technology, Shanghai, P.R. China
  • 3Department of Pharmacology, the Chinese University of Hong Kong, Hong Kong SAR, P.R. China
Weitere Informationen

Publikationsverlauf

Received: April 30, 2008 Revised: September 22, 2008

Accepted: September 26, 2008

Publikationsdatum:
24. November 2008 (online)

Abstract

Protostemonamide (1), a new protostemonine-type alkaloid, and 12 known compounds were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1 D and 2 D NMR spectral and other spectroscopic studies. The main alkaloidal constituents, protostemonine (2), stemospironine (4), and maistemonine (7), showed significant antitussive activity in a citric acid-induced guinea pig cough model following peripheral administration; stemonamine (11) had antitussive activity following i. c. v. administration.

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Prof. Dr. Yang Ye

State Key Laboratory of Drug Research

Shanghai Institute of Materia Medica

Chinese Academy of Sciences

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