Synthesis of an HIV Integrase Inhibitor

Y.-L. Zhong; B. Pipik; J. Lee; Y. Kohmura; S. Okada; K. Igawa; C. Kadowaki; A. Takezawa; S. Kato; D. A. Conlon; H. Zhou; A. O. King; R. A. Reamer; D. R. Gauthier, Jr.; D. Askin

doi:10.1055/s-0028-1088174

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Synfacts 2009(5): 0469-0469
DOI: 10.1055/s-0028-1088174

Synthesis of Natural Products and Potential Drugs

Synthesis of an HIV Integrase Inhibitor

Contributor(s): Philip Kocienski
Y.-L. Zhong*, B. Pipik, J. Lee, Y. Kohmura, S. Okada, K. Igawa, C. Kadowaki, A. Takezawa, S. Kato, D. A. Conlon, H. Zhou, A. O. King, R. A. Reamer, D. R. Gauthier, Jr., D. Askin
Merck Research Laboratories, Rahway, USA and Banyu Tsukuba Research Institute, Ibaraki, Japan

Further Information

Publication History

Publication Date:
22 April 2009 (online)

Permissions and Reprints

Significance

The target molecule is being developed by Merck as a candidate for combination treatment of AIDS. The synthesis is chromatography-free and is suitable for the preparation of multikilogram quantities of the target molecule.