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Synfacts 2009(4): 0358-0358
DOI: 10.1055/s-0028-1088084
DOI: 10.1055/s-0028-1088084
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Total Synthesis of (-)Clavirolide C
M. K. Brown, A. H. Hoveyda*
Boston College, Chestnut Hill, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. März 2009 (online)
![](https://www.thieme-connect.de/media/synfacts/200904/lookinside/thumbnails/10.1055-s-0028-1088084-1.jpg)
Significance
The first enantioselective total synthesis of (-)-clavirolide C is noteworthy for the use of different types of copper-catalyzed asymmetric conjugate additions to make both the fragments E and F as well as the final molecule. Also the phosphine-free ruthenium-based ring-closing metathesis to form the 11-membered ring is a rare example of its kind.