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Synthesis 2009(11): 1821-1828
DOI: 10.1055/s-0028-1088065
DOI: 10.1055/s-0028-1088065
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Benzopyrrolizidinones by Norrish-Yang Cyclization of 3-(Acylmethyl)-2-alkylisoindol-1-ones
Further Information
Received
25 November 2008
Publication Date:
27 April 2009 (online)
Publication History
Publication Date:
27 April 2009 (online)
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Abstract
An efficient synthesis of 2-hydroxy-1,2,3,9b-tetrahydropyrrolo[2,1-a]isoindol-5-ones has been achieved by the Norrish-Yang cyclization of 3-(acylmethyl)-2-alkylisoindol-1-ones in benzene in moderate to high yields.
Key words
Norrish-Yang cyclization - 3-(acylmethyl)-2-alkylisoindol-1-one - pyrrolo[2,1-a]isoindol-5-one - intramolecular ring formation - C-C bond formation
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