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Synthesis 2009(10): 1659-1662
DOI: 10.1055/s-0028-1088059
DOI: 10.1055/s-0028-1088059
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Straightforward and Scalable Synthesis of Orthogonally Protected 3,7-Diazabicyclo[4.1.0]heptane
Weitere Informationen
Received
26 November 2008
Publikationsdatum:
20. April 2009 (online)
Publikationsverlauf
Publikationsdatum:
20. April 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/200910/lookinside/thumbnails/10.1055-s-0028-1088059-1.jpg)
Abstract
Orthogonally N-protected (Boc and Cbz) 3,4-aziridinopiperidine is a versatile building block for the synthesis of 4-substituted 3-aminopiperidines, which are compounds with a high potential for biological activity. A multigram synthesis over five steps, starting with extraordinarily simple materials (pyridine and benzyl chloride), was developed.
Key words
amines - piperidines - aziridines - building blocks - protective groups
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