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Synthesis 2009(9): 1531-1544
DOI: 10.1055/s-0028-1088045
DOI: 10.1055/s-0028-1088045
SPECIALTOPIC
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Transfer Hydrogenation of Ketimines with Trichlorosilane: Structural Studies
Further Information
Received
7 February 2009
Publication Date:
14 April 2009 (online)
Publication History
Publication Date:
14 April 2009 (online)
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Abstract
We report structural and mechanistic studies on the organocatalytic asymmetric transfer hydrogenation of ketimines with trichlorosilane. Amines were obtained in good yields and moderate enantioselectivities. Both experiment and computation were utilized to provide an improved understanding of the mechanism.
Key words
amines - Lewis bases - organocatalysis - transfer hydrogenation - trichlorosilane
- Supporting Information for this article is available online:
- Supporting Information
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References
The geometries for structures C1˙C5a and C1˙C5b are given in the supporting information.