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Synthesis 2009(7): 1204-1208  
DOI: 10.1055/s-0028-1088006
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Microwave-Assisted Synthesis and Functionalization of Selenolopyrimidines

Stéphanie Hesse*, Célia Chenet, David Thomae, Gilbert Kirsch
Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean Barriol FR CNRS 2843, Université Paul Verlaine-Metz, 1 Boulevard Arago, 57070 Metz, France
Fax: +33(3)87315801; e-Mail: hesse@univ-metz.fr;
Further Information

Publication History

Received 20 November 2008
Publication Date:
06 March 2009 (online)

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Abstract

Microwave-assisted synthesis allowed efficient access to 4-chloroselenolo[3,2-d]pyrimidines in short times and very good yields. Some functionalizations by SNAr and palladium-catalyzed reactions are also reported.

Key words

selenium - pyrimidines - heterocycles - cyclizations - microwave­-assisted reactions

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