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Synfacts 2009(4): 0425-0425  
DOI: 10.1055/s-0028-1087824
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Efficient Cobalt-Catalyzed Coupling of Aryl Grignard Reagents with Alkyl Bromides

Contributor(s): Paul Knochel, Andrei Gavryushin
G. Cahiez*, C. Chaboche, C. Duplais, A. Moyeux
CNRS - Université de Paris 13, Bobigny, France
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Publication History

Publication Date:
23 March 2009 (online)

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Significance

An efficient cobalt-catalyzed cross-coupling reaction of aryl Grignard reagents with primary and secondary alkyl bromides is reported. The reaction proceeds rapidly under very mild conditions and tolerates many functional groups. A readily available cobalt catalyst is used in the process, which is in general more efficient and versatile than the similar iron-catalyzed sp²-sp³ cross-coupling reactions.