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Synthesis 2009(5): 836-840
DOI: 10.1055/s-0028-1087805
DOI: 10.1055/s-0028-1087805
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Angular 7,8-Pyridazinocoumarins via the Transformation of a Hydroxy Group into a Carbonyl Group
Weitere Informationen
Received
30 September 2008
Publikationsdatum:
11. Februar 2009 (online)
Publikationsverlauf
Publikationsdatum:
11. Februar 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/200905/lookinside/thumbnails/10.1055-s-0028-1087805-1.jpg)
Abstract
The synthesis of angular 7,8-pyridazinocoumarins (2H-pyrano[2,3-f]phthalazin-2-ones) is reported via the oxidation of 8-[1-(acylhydrazono)ethyl]-7-hydroxycoumarin with (diacetoxyiodo)benzene and subsequent treatment of the derived 7,8-diacylcoumarins with hydrazine. The procedure involves transformation of a hydroxy group into an acyl group and formation of a new C-C bond.
Key words
transformation - oxidation - (diacetoxyiodo)benzene - 2H-pyrano[2,3-f]phthalazin-2-ones - angular pyridazinocoumarins - N-acylhydrazones
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