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Synthesis 2009(6): 957-962  
DOI: 10.1055/s-0028-1087803
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

An Efficient and Highly Selective Synthesis of (Z)-Fluoroenol Phosphates from Hydroxy Difluorophosphonates

Petr Beier*, Radek Pohl, Anastasia V. Alexandrova
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic
Fax: +420(220)183578; e-Mail: beier@uochb.cas.cz;
Further Information

Publication History

Received 13 November 2008
Publication Date:
11 February 2009 (online)

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Abstract

Substituted 2-aryl-2-hydroxy-1,1-difluorophosphonates undergo a reaction with potassium tert-butoxide to provide selectively (Z)-2-fluoro-1-arylvinyl phosphates in high yields.

Key words

phosphonates - phosphates - rearrangements - eliminations - enols

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