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Synfacts 2009(3): 0291-0291  
DOI: 10.1055/s-0028-1087785
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

α-Fluorination of Acid Chlorides

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
D. H. Paull, M. T. Scerba, E. Alden-Danforth, L. R. Widger, T. Lectka*
Johns Hopkins University, Baltimore, USA
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Publication History

Publication Date:
19 February 2009 (online)

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Significance

Fluorinated compounds are becoming increasingly important in pharmaceutically active compounds. In this report the authors utilize a dual activation system in which a chiral nucleophile produces a chiral ketene enolate and a transition metal to activate the enolate by coordination.