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Synfacts 2009(3): 0301-0301  
DOI: 10.1055/s-0028-1087752
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Methodology for the Synthesis of Polyketide Fragments

Contributor(s): Mark Lautens, David A. Candito
J. T. Spletstoser, M. J. Zacuto, J. L. Leighton*
Columbia University, New York, USA
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Publikationsdatum:
19. Februar 2009 (online)

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Significance

This work expands the scope of tandem intramolecular silylformylation-(allyl)crotylsilylation by demonstrating that internal alkynes can be used as substrates, allowing for the generation of an additional stereocenter. The authors also demonstrate the application of this methodology to polyketide natural product synthesis.