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Synfacts 2009(3): 0235-0235  
DOI: 10.1055/s-0028-1087698
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of ()-Psychotrimine

Contributor(s): Philip Kocienski, Zofia Komsta
T. Newhouse, P. S. Baran*
The Scripps Research Institute, La Jolla, USA
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Publication History

Publication Date:
19 February 2009 (online)

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Significance

Psychotrimine was isolated from a South African rainforest shrub Psychotria rostrata, belonging to the coffee family. This very concise and high-yielding synthesis features a unique, ­direct indole-aniline coupling (A → D). More than two gram of the target molecule was obtained in four relatively high-yielding steps.