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Synfacts 2009(3): 0243-0243  
DOI: 10.1055/s-0028-1087695
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of a Platensimycin Mimic

Contributor(s): Philip Kocienski, Zofia Komsta
Y-Y. Yeung, E. J. Corey*
Harvard University, Cambridge, USA
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Publikationsverlauf

Publikationsdatum:
19. Februar 2009 (online)

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Significance

A potential antibiotic and a structural analogue of platensimycin was synthesized. The focal step of the synthesis is a highly diastereo- and enantioselective Diels-Alder cycloaddition (A + B → D).