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Synlett 2009(2): 320-327
DOI: 10.1055/s-0028-1087673
DOI: 10.1055/s-0028-1087673
NEWTOOLS
© Georg Thieme Verlag
Stuttgart ˙ New York
Catalytic Enantioselective α-Arylation of Carbonyl Compounds
Weitere Informationen
Received
21 July 2008
Publikationsdatum:
15. Januar 2009 (online)
Publikationsverlauf
Publikationsdatum:
15. Januar 2009 (online)
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Abstract
Enantioselective creation of benzylic quaternary centers still is a continuous challenge to many synthetic organic chemists. Among the existing methods for installation of this type of center, the direct asymmetric α-arylation of carbonyl compounds is very attractive due to the ready availability of the coupling substrates. Herein, we present some new tools to the catalytic asymmetric α-arylation of carbonyl compounds that overcame many of the drawbacks posted in previous methods for this type of reaction.
Key words
enolates - α-arylation - carbonyl compounds - palladium - nickel - quaternary benzylic centers
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