Synlett 2009(2): 320-327  
DOI: 10.1055/s-0028-1087673
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© Georg Thieme Verlag Stuttgart ˙ New York

Catalytic Enantioselective α-Arylation of Carbonyl Compounds

Antonio C. B. Burtoloso*
Instituto de Química de São Carlos, Universidade de São Paulo, C.P. 780, São Carlos, São Paulo, CEP 13560-970, Brasil
Fax: +55(16)33739952; e-Mail: antonio@iqsc.usp.br;
Further Information

Publication History

Received 21 July 2008
Publication Date:
15 January 2009 (online)

Abstract

Enantioselective creation of benzylic quaternary centers still is a continuous challenge to many synthetic organic chemists. Among the existing methods for installation of this type of center, the direct asymmetric α-arylation of carbonyl compounds is very attractive due to the ready availability of the coupling substrates. Herein, we present some new tools to the catalytic asymmetric α-arylation of carbonyl compounds that overcame many of the drawbacks posted in previous methods for this type of reaction.