Synlett 2009(2): 279-283  
DOI: 10.1055/s-0028-1087510
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Controlled Ring Opening of N-Sulfinyl- and N-Silyl-N-carboxyanhydrides (NCA): One-Pot Synthesis of Dipeptides and Unsymmetrical Peptidyl Ureas from Unprotected NCA

Julia Mateos-Caroa, Yves Robinb, Vincent Levacher*a, Francis Marsaisa
a Laboratoire de Chimie Organique Fine et Hétérocyclique, UMR 6014, IRCOF, CNRS, Université et INSA de Rouen, B.P. 08, 76131 Mont-Saint-Aignan Cédex, France
Fax: +33(2)35522475; e-Mail: Vincent.levacher@insa-rouen.fr;
b ISOCHEM, Centre de Recherches du Bouchet, 91710 Vert-le-Petit, France
Further Information

Publication History

Received 24 September 2008
Publication Date:
15 January 2009 (online)

Zoom Image

Abstract

We report herein new labile protecting groups of N-carboxyanhydrides (NCA) useful to prevent polymerization during coupling reactions with nitrogen nucleophiles. Thus, N-sulfinyl-NCA 1 and N-silyl-NCA 2 were prepared in situ and involved, without being isolated, in coupling reactions with various α-amino esters to furnish dipeptides 3 and unsymmetrical peptidyl ureas 4, respectively, in good yields.