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Synfacts 2009(1): 0029-0029  
DOI: 10.1055/s-0028-1087470
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart ˙ New York

Magnesium Nitride as a Source of Ammonia for the Paal-Knorr Synthesis of Pyrroles

Contributor(s): Victor Snieckus, Dmitry N. Korolev
G. E. Veitch, K. L. Bridgwood, K. Rands-Trevor, S. V. Ley*
University of Cambridge, UK
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

Reported is an improvement of the well-known Paal-Knorr protocol for the synthesis of pyrroles from 1,4-dicarbonyl compounds using magnesium nitride as a source of ammonia. The reaction is performed under conventional and ­microwave heating resulting in the products in good to excellent preparative yields. The key point of the procedure is an alcoholysis of Mg3N2 generating ammonia in situ gradually.