Synfacts 2009(1): 0089-0089  
DOI: 10.1055/s-0028-1087448
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Cross-Coupling Reactions with Enol Phosphinates

Contributor(s): Paul Knochel, Andrey Gavryushin
J. Guo, J. D. Harling, P. G. Steel*, T. M. Woods
University of Durham and GlaxoSmithKline, Herts, UK
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Publikationsverlauf

Publikationsdatum:
18. Dezember 2008 (online)

Significance

This is the first report of the use of enol phosphinates as electrophiles in cross-coupling reactions. The authors present an interesting alternative to the conventional chemistry of enol ­triflates and phosphates, which are often not sufficiently stable. The Suzuki and Stille reactions proceed fairly well with these new electrophiles, giving reasonable yields of products.