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Synfacts 2009(1): 0076-0076  
DOI: 10.1055/s-0028-1087447
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Iron-Catalyzed N-Arylation of Aryl Halides with Amines

Contributor(s): Paul Knochel, Andrey Gavryushin
D. Guo, H. Huang, J. Xu, H. Jiang, H. Liu*
shanghai institute of Materia Medica and East China University of Science and Technology, Shanghai; China Pharmaceutical University, Nanjing, P. R. of China
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

Transition-metal-catalyzed amination of aryl halides has recently become the most important industrial method of the preparation of substituted anilines. The use of iron catalysis is always very advantageous due to the low cost and toxicity of this metal. This publication describes the first Fe-catalyzed arylation of anilines. It is an important contribution to the rapidly growing field of iron catalysis in synthetic organic chemistry.