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Synfacts 2009(1): 0064-0064
DOI: 10.1055/s-0028-1087441
DOI: 10.1055/s-0028-1087441
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper(I)/Chiral Bisphosphine Catalyzed Diamination of Conjugated Dienes
H. Du, B. Zhao, W. Yuan, Y. Shi*
Colorado State University, Fort Collins, USA
Further Information
Publication History
Publication Date:
18 December 2008 (online)
Significance
The copper(I)-catalyzed enantioselective diamination of several conjugated dienes is realized (up to 74% ee are obtained) through the use of a bulky bisphosphine ligand and di-tert-butyldiaziridinone as nitrogen source. The resulting vicinal diamine products are very important chiral building blocks. Further improvement of enantioselectivity is anticipated to make this transformation more practical.