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Synfacts 2008(12): 1263-1263
DOI: 10.1055/s-0028-1087330
DOI: 10.1055/s-0028-1087330
Synthesis of Heterocycles
© Georg Thieme Verlag
Stuttgart ˙ New York
Acid-Mediated Synthesis of 3-N,N-Dialkyl-amino-1,2,4-Triazoles
D. V. Batchelor, D. M. Beal, T. B. Brown, D. Ellis, D. W. Gordon, P. S. Johnson, H. J. Mason, M. J. Ralph, T. J. Underwood, S. Wheeler*
Pfizer Global Research and Development, Sandwich, UK
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. November 2008 (online)
![](https://www.thieme-connect.de/media/synfacts/200812/lookinside/thumbnails/10.1055-s-0028-1087330-1.jpg)
Significance
Reported are acid-mediated conditions for the formation of highly substituted 1,2,4-triazoles from the reaction of S-methylisothioureas with acyl hydrazides. The starting thioureas were synthesized in excellent yield through sequential reaction of di-2-pyridyl-thiocarbonate with primary amines.