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Synfacts 2009(1): 0102-0102  
DOI: 10.1055/s-0028-1087247
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Coupling of Phenols and Aryl Halides with Nano-Copper Oxide

Contributor(s): Yasuhiro Uozumi, Takao Osako
J. Zhang, Z. Zhang, Y. Wang, X. Zheng*, Z. Wang*
University of Science and Technology of China, Hefei, P. R. of China
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

Nanocrystalline copper oxide (nano-CuO) catalyzed the Ullmann coupling of phenols with aryl halides in the presence of Cs2CO3 or KOH to afford the corresponding diaryl ethers in up to 94% yield (18 examples). In the reaction of 4-methoxyphenol with iodobenzene, the catalyst was recovered by simple centrifugation and reused four times without loss of catalytic activity. TEM analysis showed almost no changes of the shape and size of the catalyst after the 4th run.