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Synfacts 2009(1): 0003-0003  
DOI: 10.1055/s-0028-1087237
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Rubioncolin B

Contributor(s): Philip Kocienski
J.-P. Lumb, K. C. Choong, D. Trauner*
University of California at Berkeley, USA
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Publication History

Publication Date:
18 December 2008 (online)

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Significance

Rubioncolin B is isolated from the roots of Rubia species which are administered in Chinese medicine. The short synthesis depicted features the tautomerization of the p-quinone I to the o-quinone methide J which then undergoes an intramolecular Diels-Alder reaction to give the complex ring system of the target.