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DOI: 10.1055/s-0028-1084440
Inhibitors of bacterial multidrug efflux pumps from the resin glycosides of Ipomoea species
The CHCl3-soluble extract from Ipomoea murucoides Roemer & Schultes, through preparative-scale recycling HPLC, yielded six new pentasaccharides, murucoidins VI-XI, as well as the known pescaprein III, stoloniferin I and murucoidins I-V. Their structures were characterized through the interpretation of their NMR spectroscopic and FABMS data. All members of the murucoidin series exerted a potentiation effect of norfloxacin against the NorA over-expressing Staphylococcus aureus strain SA-1199B by increasing the activity 4-fold (8µg/mL from 32µg/mL) at concentrations of 5–25µg/mL. Therefore, this type of compounds could be developed to provide potent inhibitors of this multidrug efflux pump.
Acknowledgement: Consejo Nacional de Ciencia y Tecnología (45861-Q) and DGAPA, UNAM (IN208307).