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Synfacts 2008(11): 1192-1192
DOI: 10.1055/s-0028-1083448
DOI: 10.1055/s-0028-1083448
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Ruthenium-Lithium Complex for the Cyanosilylation of Aldehydes
N. Kurono, K. Arai, M. Uemura, T. Ohkuma*
Hokkaido University, Sapporo, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Oktober 2008 (online)
Significance
A column-stable ruthenium BINAP derived complex was found to be active for the cyanosilylation of aldehydes with exceptional enantioselectivities using a minimal amount of catalyst. The authors performed the reaction on gram scale giving high yields and enantioselectivities. The ruthenium or lithium salt alone provided inferior results and, thus, act together as a more active catalyst.