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Synfacts 2008(11): 1182-1182  
DOI: 10.1055/s-0028-1083432
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Stereoselective Olefination Promoted by Rieke Manganese

Contributor(s): Mark Lautens, Praew Thansandote
J. M. Concellón*, H. Rodríguez-Solla, P. Díaz
Universidad de Oviedo, Spain
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Publication History

Publication Date:
23 October 2008 (online)

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Significance

A Rieke manganese promoted stereoselective synthesis of (Z)-α-haloacrylic esters and amides is presented. The reaction shows good yields and excellent cis-to-trans selectivity ratios. Two limitations are that ketones cannot be used and only trichloroacetates have a broad scope for both reactions. Several post-modifications of the products are reported.