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Synfacts 2008(11): 1132-1132  
DOI: 10.1055/s-0028-1083417
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of (-)-Platensimycin

Contributor(s): Philip Kocienski, Stewart Eccles
C. H. Kim, K. P. Jang, S. Y. Choi, Y. K. Chung, E. Lee*
Seoul National University, Korea
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Publication History

Publication Date:
23 October 2008 (online)

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Significance

Platensimycin was isolated from Streptomyces platensis. It is a potent antibiotic against a wide range of bacteria. Platensimycin has attracted a great deal of synthetic interest recently with many total syntheses published. This paper describes a novel [3+2]-dipolar cycloaddition pathway to the enone K, which was previously converted into (-)-platencimycin by Nicolaou and co-workers.